Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

Nano-Micro Letters

Sae Kwang Ku¹  Chul Soon Yong²  Jong Oh Kim²  Wenquan Ou²  Jeong Hoon Byeon³  Dae Hoon Park⁴  Jungho Hwang⁴  Kang Sik Nam⁴ 

[1] College of Korean Medicine, Daegu Haany University, 38610, Gyeongsan, Republic of Korea;College of Pharmacy, Yeungnam University, 38541, Gyeongsan, Republic of Korea;School of Mechanical Engineering, Yeungnam University, 38541, Gyeongsan, Republic of Korea;School of Mechanical Engineering, Yonsei University, 03722, Seoul, Republic of Korea;

关键词: Cancer immunotherapies;    Air–liquid two-phase electrospray;    Paclitaxel-loaded fake blood cell Eudragit particle;    Translatable chemo-immunotherapeutic nanosystems;    Anti-PD-L1 antibodies;   

DOI  :  10.1007/s40820-020-00428-y

来源: Springer

【 摘 要 】

HighlightsA two-phase coaxial electrospray was designed to produce paclitaxel-loaded fake blood cell Eudragit particles (Eu-FBCP/PTX).The chemo-immunotherapeutic efficacy was further enhanced after combining with anti-programmed death-ligand 1 antibodies (Eu-FBCP/PTX + aPL).

【 授权许可】

CC BY