Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Clinical and Translational Allergy

Carmen Rondon¹  Paloma Campo¹  Kristian Aasbjerg²  Ludger Klimek³  Valerie Hox⁴  Job F. M. van Boven⁵  Peter Hellings⁶  Wytske Fokkens⁷  Evelijn Lourijsen⁷  Claire Hopkins⁸  Ioana Agache⁹  Martin Wagenmann^1,10  Joaquim Mullol^1,11  Laura Pujols^1,11  Isam Alobid^1,12  Michael Rudenko^1,13  Peter-Valentin Tomazic^1,14  Koen Boussery^1,15  Sophie Scheire^1,15  Glenis Scadding^1,16  Mika Mäkelä^1,17  Sanna Toppila-Salmi^1,17  Ralph Mösges^1,18  Philippe Gevaert^1,19  Thibaut Van Zele^1,19  Arnout Jordens^1,19  Claus Bachert^2,20 

[1] Allergy Unit, Hospital Regional Universitario of Málaga, IBIMA, ARADyAL, Malaga, Spain;Bispebjerg University Hospital, Copenhagen, Denmark;Center of Rhinology and Allergology, Wiesbaden, Germany;Cliniques Universitaires Saint-Luc Brussels, Av. Hippocrate 10, 1200, Brussels, Belgium;Department of Clinical Pharmacy & Pharmacology, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, Groningen, The Netherlands;Department of Ear, Nose and Throat Disease, University Hospitals, Louvain, Belgium;Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, The Netherlands;ENT Department, Guy’s & St Thomas’ Hospital, London, UK;Faculty of Medicine, Transsylvania University, Brasov, Romania;Heinrich-Heine-University, Düsseldorf, Germany;Hospital Clínic, IDIBAPS, CEBERES Universitat de Barcelona, Catalonia, Spain;Hospital Clínic, IDIBAPS, CEBERES Universitat de Barcelona, Catalonia, Spain;Centro Medico Teknon, Barcelona, Spain;London Allergy and Immunology Center, London, UK;Medical University Graz, Graz, Austria;Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium;Royal National Throat, Nose and Ear Hospital, London, UK;Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;University of Cologne, Cologne, Germany;Upper Airway Research Laboratory, Dep. of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium;Upper Airway Research Laboratory, Dep. of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium;Department of Ear, Nose and Throat Diseases, Karolinska University Hospital, Stockholm, Sweden;

关键词: Glucocorticosteroids;    Rhinitis;    Rhinosinusitis;   

DOI  :  10.1186/s13601-019-0303-6

来源: Springer

【 摘 要 】

Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that—potentially severe—side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking. Therefore, a panel of international experts in the field of Rhinology reviewed the available literature with the aim of providing recommendations for the use of systemic steroids in treating upper airway disease.

【 授权许可】

CC BY