Treatment of spinal cord injury with mesenchymal stem cells

Cell & Bioscience

Min Hwei Ng¹  Jia Xian Law¹  Thayaalini Subramaniam¹  Ling Ling Liau²  Wui Chuen Chia³  Qi Hao Looi³ 

[1] Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, JalanYaacob Latif, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia;Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Kuala Lumpur, Malaysia;Ming Medical Services Sdn. Bhd., Pusat Perdagangan Dana 1, 47301, Petaling Jaya, Selangor, Malaysia;

关键词: Spinal cord injury;    Stem cell therapy;    Mesenchymal stem cells;    Nerve regeneration;   

DOI  :  10.1186/s13578-020-00475-3

来源: Springer

【 摘 要 】

BackgroundSpinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.ResultsThis review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied together with MSCs to enhance its efficacy. Bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UC-MSCs) and adipose tissue-derived MSCs (ADSCs) have been trialed for the treatment of SCI. Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation. Additionally, MSCs have been shown to differentiate into neuron-like cells and stimulate neural stem cell proliferation to rebuild the damaged nerve tissue.ConclusionThese characteristics are crucial for the restoration of spinal cord function upon SCI as damaged cord has limited regenerative capacity and it is also something that cannot be achieved by pharmacological and physiotherapy interventions. New biological therapies including stem cell secretome therapy, immunotherapy and scaffolds can be combined with MSC therapy to enhance its therapeutic effects.

【 授权许可】

CC BY