ADIPOQ single nucleotide polymorphisms and breast cancer in northeastern Mexican women

BMC Medical Genetics

Iram Pablo Rodríguez-Sánchez¹  Karen Paola Camarillo-Cárdenas¹  Mónica Patricia Villarreal-Vela¹  Ricardo M. Cerda-Flores²  Hazyadee Frecia Rodríguez-Gutierrez³  Oscar Vidal Gutierrez³  María Lourdes Garza-Rodríguez³  Juan Francisco González-Guerrero³  Juan Carlos Arellano-Barrientos³  Gabriela Gutiérrez-Orozco⁴  Marco Antonio Ponce-Camacho⁵  Raquel Garza-Guajardo⁵  Ana Laura Calderón-Garcidueñas⁶  Ana Lilia Castruita-Ávila⁷  Hugo Alberto Barrera Saldaña⁸ 

[1]Facultad de Ciencias Biológicas, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

[2]Facultad de Enfermería, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

[3]Facultad de Medicina y Hospital Universitario “Dr. José Eleuterio González”, Centro Universitario Contra el Cáncer (CUCC), Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

[4]Facultad de Medicina y Hospital Universitario “Dr. José Eleuterio González”, Departamento de Bioquímica Monterrey, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

[5]Facultad de Medicina y Hospital Universitario “Dr. José Eleuterio González”, Servicio de Anatomía Patológica y Citopatología, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico

[6]Facultad de Medicina, Universidad Veracruzana, Boca del Río, Veracruz, Mexico

[7]Mexican Institute of Social Security, Hospital de Especialidades No 25, Monterrey, Nuevo León, Mexico

[8]Vitagénesis SA, Monterrey, Nuevo León, Mexico

[9]LANSEIDI FarbBiotec at Innbiogem, Monterrey, Nuevo León, Mexico

[10]Centro de Biotecnología Genómica del Instituto Politécnico Nacional (IPN), Reynosa, Tamaulipas, Mexico

关键词: Breast cancer;    Single nucleotide polymorphisms;    Adiponectin;    ADIPOQ;    Mexican women;   

DOI  :  10.1186/s12881-020-01125-8

来源: Springer

【 摘 要 】

BackgroundAdiponectin gene (ADIPOQ) polymorphisms have been shown to affect adiponectin serum concentration and some have been associated with breast cancer (BC) risk. The aims of this study were to describe the frequency of single nucleotide polymorphisms (SNPs) of ADIPOQ in Mexican women with BC and to determine if they show an association with it.MethodsDNA samples from 397 patients and 355 controls were tested for the ADIPOQ gene SNPs: rs2241766 (GT) and rs1501299 (GT) by TaqMan allelic discrimination assay. Hardy–Weinberg equilibrium (HWE) was tested. Multiple SNP inheritance models adjusted by age and body mass index (BMI) were examined for the SNP rs1501299.ResultsWe found that in the frequency analysis of rs1501299 without adjusting the BMI and age, the genotype distribution had a statistically significant difference (P = 0.003). The T allele was associated with a BC risk (OR, 1.99; 95% CI 1.13–3.51, TT vs. GG; OR, 1.53; 95% CI 1.12–2.09, GT vs. GG). The SNP rs2241766 was in HW disequilibrium in controls. In conclusion, the rs1501299 polymorphism is associated with a BC risk.ConclusionsIdentification of the genotype of these polymorphisms in patients with BC can contribute to integrate the risk profile in both patients and their relatives as part of a comprehensive approach and increasingly more personalized medicine.

【 授权许可】

CC BY