Cost-effectiveness analysis of systematic fast-track transition from oncological treatment to specialised palliative care at home for patients and their caregivers: the DOMUS trial

BMC Palliative Care

Per Sjøgren¹  Hans Von Der Maase¹  Christoffer Johansen²  Helle Timm³  Christine Marie Bækø Halling⁴  Rasmus Trap Wolf⁴  Jakob Kjellberg⁴ 

[1] Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark;Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;The Danish Cancer Society, Copenhagen, Denmark;REHPA - The Danish Knowledge Centre for Rehabilitation and Palliative Care, Copenhagen, Denmark;VIVE – The Danish Center for Social Science Research, Herluf Trolles Gade 11, 1052, København K, Denmark;

关键词: Cancer;    Informal Care;    Economic evaluation;    Effectiveness;    Utility;    QALY;    Accelerated;    Palliative care;    Psychological intervention;   

DOI  :  10.1186/s12904-020-00645-7

来源: Springer

【 摘 要 】

BackgroundWhile hospitals remain the most common place of death in many western countries, specialised palliative care (SPC) at home is an alternative to improve the quality of life for patients with incurable cancer. We evaluated the cost-effectiveness of a systematic fast-track transition process from oncological treatment to SPC enriched with a psychological intervention at home for patients with incurable cancer and their caregivers.MethodsA full economic evaluation with a time horizon of six months was performed from a societal perspective within a randomised controlled trial, the DOMUS trial (Clinicaltrials.gov: NCT01885637). The primary outcome of the health economic analysis was a incremental cost-effectiveness ratio (ICER), which is obtained by comparing costs required per gain in Quality-Adjusted Life Years (QALY). The costs included primary and secondary healthcare costs, cost of intervention and informal care from caregivers. Public transfers were analysed in seperate analysis. QALYs were measured using EORTC QLQ-C30 for patients and SF-36 for caregivers. Bootstrap simulations were performed to obtain the ICER estimate.ResultsIn total, 321 patients (162 in intervention group, 159 in control group) and 235 caregivers (126 in intervention group, 109 in control group) completed the study. The intervention resulted in significantly higher QALYs for patients when compared to usual care (p-value = 0.026), while being more expensive as well. In the 6 months observation period, the average incremental cost of intervention compared to usual care was €2015 per patient (p value < 0.000). The mean incremental gain was 0.01678 QALY (p-value = 0.026). Thereby, the ICER was €118,292/QALY when adjusting for baseline costs and quality of life. For the caregivers, we found no significant differences in QALYs between the intervention and control group (p-value = 0.630). At a willingness to pay of €80,000 per QALY, the probability that the intervention is cost-effective lies at 15% in the base case scenario.ConclusionThis model of fast-track SPC enriched with a psychological intervention yields better QALYs than usual care with a large increase in costs.Trial registrationThe trial was prospectively registered 25.6.2013. Clinicaltrials.gov Identifier: NCT01885637.

【 授权许可】

CC BY