Local myocardial stiffness variations identified by high frame rate shear wave echocardiography

Cardiovascular Ultrasound

Johan G. Bosch¹  Hendrik J. Vos¹  Nico de Jong¹  Mihai Strachinaru²  Lida Feyz²  Arend F. L. Schinkel²  Marcel L. Geleijnse²  Michelle Michels² 

[1] Erasmus MC Rotterdam, Biomedical Engineering, Rotterdam, The Netherlands;Erasmus MC Rotterdam, Cardiology, Postbus 2040, 3000, Rotterdam, CA, The Netherlands;

关键词: Naturally-occurring shear waves;    Elastography;    High frame rate tissue Doppler;    Septal reduction;   

DOI  :  10.1186/s12947-020-00222-1

来源: Springer

【 摘 要 】

BackgroundShear waves are generated by the closure of the heart valves. Significant differences in shear wave velocity have been found recently between normal myocardium and disease models of diffusely increased muscle stiffness. In this study we correlate in vivo myocardial shear wave imaging (SWI) with presence of scarred tissue, as model for local increase of stiffness. Stiffness variation is hypothesized to appear as velocity variation.MethodsTen healthy volunteers (group 1), 10 hypertrophic cardiomyopathy (HCM) patients without any cardiac intervention (group 2), and 10 HCM patients with prior septal reduction therapy (group 3) underwent high frame rate tissue Doppler echocardiography. The SW in the interventricular septum after aortic valve closure was mapped along two M-mode lines, in the inner and outer layer.ResultsWe compared SWI to 3D echocardiography and strain imaging. In groups 1 and 2, no change in velocity was detected. In group 3, 8/10 patients showed a variation in SW velocity. All three patients having transmural scar showed a simultaneous velocity variation in both layers. Out of six patients with endocardial scar, five showed variations in the inner layer.ConclusionLocal variations in stiffness, with myocardial remodeling post septal reduction therapy as model, can be detected by a local variation in the propagation velocity of naturally occurring shear waves.

【 授权许可】

CC BY