Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer

Respiratory Research

Yuji Ishimatsu¹  Kaori Ishida²  Daisuke Okuno³  Yoshiko Akiyama³  Hiroshi Mukae³  Takashi Kido³  Noriho Sakamoto³  Hiroyuki Yamaguchi³  Taiga Miyazaki³  Yasushi Obase³  Takuto Miyamura³  Hiroshi Ishimoto³  Atsuko Hara³  Tomoyuki Kakugawa⁴  Takuro Miyazaki⁵  Takeshi Nagayasu⁵  Keitaro Matsumoto⁵  Tomoshi Tsuchiya⁵  Hirokazu Taniguchi⁶ 

[1] Department of Nursing, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8520, Nagasaki, Japan;Department of Pathology and Laboratory Medicine, Kansai Medical University, 2-5-1 Shinmachi, 574-1191, Hirakata City, Osaka, Japan;Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan;Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan;Department of Pulmonology and Gerontology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minamikogushi, 755-8505, Ube City, Yamaguchi, Japan;Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan;Molecular Pharmacology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY10065, New York, USA;

关键词: Lung cancer;    Molecular biology;    Pathology;    Pulmonary fibrosis;    Thoracic surgery;   

DOI  :  10.1186/s12931-020-01490-1

来源: Springer

【 摘 要 】

BackgroundHeat shock protein 47 (HSP47), a collagen-binding protein, has a specific role in the intracellular processing of procollagen production. HSP47 expression is associated with cancer growth and metastasis in several types of cancers. However, none of the studies have assessed whether HSP47 expression is associated with the risk of postoperative recurrence of lung cancer until now. Therefore, we aimed to assess this association.MethodsThe study population consisted of a cohort of consecutive patients who underwent surgery for lung cancer at Nagasaki University Hospital, Nagasaki, Japan, from January 2009 to December 2010. Patient characteristics, survival and disease-free survival (DFS), and laboratory findings were compared between patients who tested positive and negative for HSP47 expression in lung cancer cells and between those who showed high and low numbers of HSP47-positive fibroblasts in cancer stroma.ResultsA total of 133 patients underwent surgery for lung cancer. Sixty-seven patients (50.4%) had HSP47-positive cancer cells, and 91 patients (68.4%) had a higher number of HSP47-positive fibroblasts. The patients with a high number of HSP47-positive fibroblasts had a shorter DFS than those with a low number of HSP47-positive fibroblasts. Multivariate analysis identified only the presence of a high number of HSP47-positive fibroblasts as an independent risk factor for recurrence of lung cancer after surgery (odds ratio, 4.371; 95% confidence interval, 1.054–29.83; P = 0.042).ConclusionThe present study demonstrated that the presence of a high number of HSP47-positive fibroblasts in the cancer stroma was a risk factor for recurrence of lung cancer after surgery.

【 授权许可】

CC BY