Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities

Natural Products and Bioprospecting

Lígia Salgueiro¹  Célia Cabral²  Mohammad Sanad Abu-Darwish³  Thomas Efferth⁴  Mei Wang⁵  Babu L. Tekwani⁵  Zulfigar Ali⁵  Melissa R. Jacob⁵  Fazila Zulfiqar⁵  Shabana I. Khan⁵  Surendra K. Jain⁵  Ikhlas A. Khan⁵  Hatem Taifour⁶ 

[1] CIEPQPF/Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de S. Comba, 3000-548, Coimbra, Portugal;Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548, Coimbra, Portugal;Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548, Coimbra, Portugal;Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal;Department of Basic and Applied Sciences, Al-Balqa Applied University, 19117, Al-Salt, Jordan;National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 38677, University, MS, USA;Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biocmedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany;National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 38677, University, MS, USA;School of Geosciences, University of Edinburgh, 219 Crew Building, King’s Buildings, EH9 3FF, Edinburgh, UK;

关键词: Lamiaceae;    Essential oil;    Chemical composition;    Cytotoxicity;    Anti-inflammatory activity;    Neglected diseases;   

DOI  :  10.1007/s13659-020-00259-9

来源: Springer

【 摘 要 】

In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC–MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it’s predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC50 90 µg/mL) and NF-κB activity (IC50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.

【 授权许可】

CC BY