Association of plasma chromium with metabolic syndrome among Chinese adults: a case-control study

Nutrition Journal

Jiawei Yin¹  Wei Yang¹  Li Zhou¹  Sijing Chen¹  Shuzhen Li¹  Mengke Wang¹  Yalun Zhu¹  Xiaobo Peng¹  Zhilei Shan¹  Can Fang¹  Liegang Liu¹  Qianqian Guo¹  Xiaoyi Chen²  Yan Zhang³ 

[1] Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China;Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China;Department of Nutrition and Food Hygiene, School of Public Health, Guangzhou Medical University, 511436, Guangzhou, China;The Hubei Provincial Key Laboratory of Yeast Function, 443003, Yichang, Hubei, China;

关键词: Chromium;    Metabolic syndrome;    High blood glucose;    Lipid;   

DOI  :  10.1186/s12937-020-00625-w

来源: Springer

【 摘 要 】

BackgroudChromium has been suggested playing a role in alleviating diabetes, insulin resistance and lipid anomalies, but the effect on metabolic syndrome (MetS) in humans remains controversial.MethodsWe conducted a matched case-control study in a Chinese population, involving 2141 MetS cases and 2141 healthy controls, which were 1:1 matched by age (±2 years) and sex. Plasma chromium was measured by inductively coupled plasma mass spectrometry.ResultsPlasma chromium levels were lower in MetS group than in control group (mean: 4.36 μg/L and 4.66 μg/L, respectively, P < 0.001), and progressively decreased with the number of MetS components (P for trend < 0.001). After adjustment for potential confounding factors, the odds ratios (95% confidence intervals) for MetS across increasing quartiles of plasma chromium levels were 1 (reference), 0.84 (0.67–1.05), 0.76 (0.61–0.95), and 0.62 (0.49–0.78), respectively (P for trend < 0.001). For the components of MetS (high waist circumference, high triglycerides and high blood glucose), the odds ratios (95% confidence intervals) of the highest quartiles were 0.77 (0.61–0.95), 0.67 (0.55–0.80), and 0.53 (0.44–0.64), respectively (P for trend < 0.05).ConclusionsOur results indicated that plasma chromium levels were inversely associated with MetS in Chinese adults. The association may be explained by the relations between plasma chromium levels and high waist circumference, and the triglycerides and blood glucose levels.

【 授权许可】

CC BY