High prevalence of hepatitis A in indigenous population in north Brazil

BMC Research Notes

Guilherme de Macêdo Oliveira¹  Flavio Augusto Pádua Milagres²  Anselmo Rocha Romão³  Monica de Avelar Figueiredo Mafra Magalhães³  Renata Gracie³  Livia Melo Villar⁴  Juliana Custódio Miguel⁴  Helena Medina Cruz⁴  Vanessa Alves Marques⁴  Leticia de Paula Scalioni⁵  Vanessa Salete de Paula⁶ 

[1] Cancer Nacional Institute, INCA, Rio de Janeiro, Brazil;Federal University of Tocantins, UFT, Tocantins, Brazil;Laboratory of Information in Health, Institute of Communication and Technological and Scientific Information in Health (ICICT), FIOCRUZ, Rio de Janeiro, Brazil;Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, FIOCRUZ, Helio and Peggy Pereira Pavillion, Ground Floor, Room B09, FIOCRUZ Av. Brasil, 4365 - Manguinhos, 210360-040, Rio de Janeiro, Brazil;Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, FIOCRUZ, Helio and Peggy Pereira Pavillion, Ground Floor, Room B09, FIOCRUZ Av. Brasil, 4365 - Manguinhos, 210360-040, Rio de Janeiro, Brazil;Hepatology Research Group, University of Plymouth, Plymouth, Devon, UK;Molecular Virology Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil;

关键词: Hepatitis A;    Prevalence;    Indigenous population;    Vaccination;   

DOI  :  10.1186/s13104-020-05303-y

来源: Springer

【 摘 要 】

ObjectivesLittle is known about hepatitis A virus (HAV) prevalence in indigenous communities. This study aims to evaluate the prevalence of HAV in indigenous community compared to urban population located at Western Amazon in Brazil.ResultsA total of 872 serum samples were obtained from 491 indigenous and 381 non indigenous individuals aging 0 to 90 years. Samples were tested for total and IgM anti-HAV and positive IgM samples were tested for HAV RNA. The overall prevalence of total anti-HAV was 87%, increased according age showing 100% of prevalence in those aging more than 30 years (p < 0.0001) and it was similar among indigenous and urban population. Total anti-HAV prevalence varied between tribes (p < 0.0001) and urban sites (p = 0.0014) and spatial distribution showed high prevalence in homes that received up to 100 dollars. IgM anti-HAV prevalence was 1.7% with predominance in males, those aging more than 41 years. No HAV RNA was detected. In conclusion, high overall anti-HAV prevalence was found in indigenous communities in North Brazil demonstrating the importance of universal vaccination in this group.

【 授权许可】

CC BY