Low and very low birth weight in puppies: definitions, risk factors and survival in a large-scale population

BMC Veterinary Research

Faouzi Lyazrhi¹  Aurélien Grellet²  Florine Guiraud²  Hanna Mila²  Amélie Mugnier²  Sylvie Chastant-Maillard²  Virginie Gaillard³  Achraf Adib-Lesaux³  Claude Saegerman⁴ 

[1] Biostatistiques, Université de Toulouse, ENVT, 23 Chemin des Capelles, Toulouse, France;NeoCare, Université de Toulouse, ENVT, 23 Chemin des Capelles, Toulouse, France;Royal Canin, 650 Avenue de la Petite Camargue, 30470, Aimargues, France;UREAR-ULiège, FARAH Center, Faculté de Médecine Vétérinaire, Université de Liège, B42, Quartier Vallée 2, Avenue de Cureghem 7A, 4000, Liège, Belgium;

关键词: Canine;    Puppy;    Epidemiology;    Risk factor;    Neonatal mortality;    Litter size;    Birth weight;   

DOI  :  10.1186/s12917-020-02577-z

来源: Springer

【 摘 要 】

BackgroundNeonatal mortality (over the first three weeks of life) is a major concern in canine breeding facilities as an economic and welfare issue. Since low birth weight (LBW) dramatically increases the risk of neonatal death, the risk factors of occurrence need to be identified together with the chances and determinants of survival of newborns at-risk.ResultsData from 4971 puppies from 10 breeds were analysed. Two birth weight thresholds regarding the risk of neonatal mortality were identified by breed, using respectively Receiver Operating Characteristics and Classification and Regression Tree method. Puppies were qualified as LBW and very low birth weight (VLBW) when their birth weight value was respectively between the two thresholds and lower than the two thresholds. Mortality rates were 4.2, 8.8 and 55.3%, in the normal, LBW and VLBW groups, accounting for 48.7, 47.9 and 3.4% of the included puppies, respectively. A separate binary logistic regression approach allowed to identify breed, gender and litter size as determinants of LBW. The increase in litter size and being a female were associated with a higher risk for LBW. Survival for LBW puppies was reduced in litters with at least one stillborn, compared to litters with no stillborn, and was also reduced when the dam was more than 6 years old. Concerning VLBW puppies, occurrence and survival were influenced by litter size. Surprisingly, the decrease in litter size was a risk factor for VLBW and also reduced their survival. The results of this study suggest that VLBW and LBW puppies are two distinct populations. Moreover, it indicates that events and factors affecting intrauterine growth (leading to birth weight reduction) also affect their ability to adapt to extrauterine life.ConclusionThese findings could help veterinarians and breeders to improve the management of their facility and more specifically of LBW puppies. Possible recommendations would be to only select for reproduction dams of optimal age and to pay particular attention to LBW puppies born in small litters. Further studies are required to understand the origin of LBW in dogs.

【 授权许可】

CC BY