Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study

Pilot and Feasibility Studies

Charity I. Oyedeji¹  John J. Strouse²  Alison Luciano³  Miriam C. Morey⁴  Katherine Hall⁴ 

[1] Department of Medicine, Division of Hematology, Duke University School of Medicine, 315 Trent Dr. Suite 261, DUMC Box 3939, 27710, Durham, NC, USA;Duke Claude D. Pepper Older Americans Independence Center, Durham, NC, USA;Department of Medicine, Division of Hematology, Duke University School of Medicine, 315 Trent Dr. Suite 261, DUMC Box 3939, 27710, Durham, NC, USA;Duke Claude D. Pepper Older Americans Independence Center, Durham, NC, USA;Department of Medicine, and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC, USA;Division of Pediatric Hematology-Oncology, Duke University, Durham, NC, USA;Duke Claude D. Pepper Older Americans Independence Center, Durham, NC, USA;Duke Claude D. Pepper Older Americans Independence Center, Durham, NC, USA;Department of Medicine, Division of Geriatrics, Duke University, Durham, NC, USA;Geriatric Research, Education and Clinical Center, Durham Veterans Affairs Healthcare System, Durham, NC, USA;

关键词: Sickle cell;    Geriatrics;    Aging;    Older adults;    Geriatric assessment;    Functional assessment;   

DOI  :  10.1186/s40814-020-00673-3

来源: Springer

【 摘 要 】

BackgroundThe life expectancy for people with sickle cell disease (SCD) has improved tremendously over the last 50 years. This population experiences hemolysis and vaso-occlusion in multiple organs that lead to complications such as cardiopulmonary disease, strokes, and avascular necrosis. These complications can limit mobility and aerobic endurance, similar to limitations that often occur in geriatric populations. These sickle-cell and age-related events lead to frequent hospitalization, which further increases the risk of functional decline. We have few tools to measure functional decline in people with SCD. The purpose of this paper is to describe a protocol to evaluate the feasibility of sickle cell disease geriatric assessment (SCD-GA).Methods/designWe will enroll 40 adults with SCD (20 age 18–49.99 years and 20 age ≥ 50 years) in a prospective cohort study to assess the feasibility of SCD-GA. The SCD-GA includes validated measures from the oncology geriatric assessment enriched with additional physical and cognitive measures. The SCD-GA will be performed at the first study visit, at 10 to 20 days after hospitalization, and at 12 months (exit visit). With input from a multidisciplinary team of sickle cell specialists, geriatricians, and experts in physical function and physical activity, we selected assessments across 7 domains: functional status (11 measures), comorbid medical conditions (1 measure), psychological state (1 measure), social support (2 measures), weight status (2 measures), cognition (3 measures), and medications (1 measure). We will measure the proportion completing the assessment with feasibility as the primary outcome. Secondary outcomes include the proportion consenting and completing all study visits, duration of the assessment, acceptability, and adverse events.DiscussionWe present the protocol and rationale for selection of the measures included in SCD-GA. We also outline the methods to determine feasibility and subsequently to optimize the SCD-GA in preparation for a larger multicenter validation study of the SCD-GA.

【 授权许可】

CC BY