Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy

Nano-Micro Letters

Yong Li¹  Juan Li¹  Bo Yuan¹  Aiguo Wu¹  Shiyu Du¹  Zhenni Wei¹  Nianxiang Qiu¹  Li Sun²  Yanyin Li²  Zhenqi Jiang²  Yinjie Wang²  Jianjun Zheng³  Yinhua Jin³ 

[1] Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 315201, Ningbo, People’s Republic of China;Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 315201, Ningbo, People’s Republic of China;University of Chinese Academy of Sciences, 100049, Beijing, People’s Republic of China;Hwa Mei Hospital, University of Chinese Academy of Sciences, 315010, Ningbo, People’s Republic of China;

关键词: Zeolitic imidazolate frameworks-90;    Drug delivery;    Magnetic resonance imaging;    pH-responsive release;    Y receptor ligand;   

DOI  :  10.1007/s40820-019-0292-y

来源: Springer

【 摘 要 】

tsManganese-zeolitic imidazolate frameworks (Mn-ZIF-90) with both high drug loading and magnetic resonance imaging (MRI) in vitro and in vivo were prepared.The modification of a newly designed pH-protective and active-targeting Y1 receptor ligand reduces the drug release during blood circulation and specifically targets the tumor sites, improving therapeutic efficacy in vivo.The combination of nano-size Mn-ZIF-90 and the highly specific Y1 receptor ligand promotes the specific drug accumulation in tumor sites.

【 授权许可】

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