Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital

Journal of Occupational Medicine and Toxicology

Ai Hori¹  Mari Shimura²  Kazuhiko Yamada³  Kyoko Nohara³  Shotaro Hagiwara⁴  Junko Shirataki⁵  Yutaka Iida⁵  Takayuki Ichinose⁵  Ai Yamashita⁵ 

[1] Department of Epidemiology and Prevention, National Center for Global Health and Medicine (NCGM), Tokyo, Japan;Department of Global Public Health, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, 305-8577, Tsukuba, Ibaraki, Japan;Department of Intractable Diseases, NCGM, 1-21-1, Toyama, Shinjuku-ku, 162-8655, Tokyo, Japan;Department of Surgery, Hospital, NCGM, Tokyo, Japan;Division of Hematology, Internal Medicine, Hospital, NCGM, Tokyo, Japan;Present address: Department of Hematology, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan;Inorganic Analysis Laboratories, Toray Research Center, Inc., Otsu, Japan;

关键词: Platinum;    Anti-cancer drug;    Hospital;    Hair;    Inductively coupled plasma mass spectrometry;   

DOI  :  10.1186/s12995-020-00280-1

来源: Springer

【 摘 要 】

BackgroundOccupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers.MethodsHospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry.ResultsPlatinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers (P = 0.045), although 50 times lower than that from PDs-treated patients. Platinum concentrations in the hospital environment had decreased at the second survey 5 years later but had not changed significantly in the hair samples from hospital workers.ConclusionPlatinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers’ hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues.

【 授权许可】

CC BY