Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model

BMC Research Notes

Elly Marcq¹  Carolyn J. Peddle-McIntyre²  Robert U.  Newton³  Richard A. Lake⁴  Scott A. Fisher⁵  Kimberley Burton⁵  Anna K. Nowak⁶ 

[1] Centre for Oncological Research, University of Antwerp, Antwerp, Belgium;Exercise Medicine Research Institute, Edith Cowan University, Perth, Australia;School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia;Exercise Medicine Research Institute, Edith Cowan University, Perth, Australia;School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia;School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, QLD, Australia;National Centre for Asbestos Related Diseases (NCARD), Perth, Australia;National Centre for Asbestos Related Diseases (NCARD), Perth, Australia;School of Biomedical Sciences, University of Western Australia, Perth, Australia;National Centre for Asbestos Related Diseases (NCARD), Perth, Australia;School of Medicine, University of Western Australia, Perth, Australia;

关键词: Asbestos;    Mesothelioma;    Exercise;    MexTAg;   

DOI  :  10.1186/s13104-020-05284-y

来源: Springer

【 摘 要 】

ObjectiveThere is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations. Long latency periods associated with carcinogen–induced cancers like asbestos induced mesothelioma provide an opportunity to implement exercise as an intervention to delay or prevent disease development. However, there are limited studies investigating the ability of exercise to prevent or delay cancer, and exercise as a preventive strategy has never been assessed in models with a known carcinogen. We investigated the potential of voluntary exercise (VE) to delay development of asbestos related disease (ARD) in our well-characterised, asbestos induced MexTAg model of mesothelioma.ResultsAsbestos exposed MexTAg mice were given continuous or delayed access to VE and ARD assessed over time. We found that the addition of VE did not affect ARD development in asbestos exposed MexTAg mice. However, non–asbestos exposed, aged matched control mice participated in significantly more VE behaviours, suggesting subclinical development of ARD after asbestos exposure had a greater impact on VE participation than age alone. These data highlight the importance of model choice and the potential limitation that some pre–clinical studies may not accurately represent the clinical paradigm, particularly in the context of prevention studies.

【 授权许可】

CC BY