Correlation between peripheral blood neutrophil-lymphocyte ratio and CD34 expression in prostate cancer

BMC Cancer

Kang Peng¹  Xiaolei Sun²  Renfu Chen²  Xiaofei Dong³  Zhaokui Qu⁴  Yiyang Wang⁵ 

[1] Department of Urology, Xuzhou Medical College, 221000, Xuzhou, Jiangsu, China;Department of Urology, Xuzhou Medical College, 221000, Xuzhou, Jiangsu, China;Department of Urology, Affiliated Hospital of Xuzhou Medical College, 99 Huaihai Road, 221000, Xuzhou, Jiangsu Province, People’s Republic of China;Department of Urology, Xuzhou Medical College, 221000, Xuzhou, Jiangsu, China;Department of Urology, Xuzhou City Hospital of traditional Chinese Medicine, 221000, Xuzhou, Jiangsu, China;Department of Urology, Yancheng Third People’s Hospital, 224000, Yancheng, Jiangsu, China;Department of Urology, Yancheng Third People’s Hospital, 224000, Yancheng, Jiangsu, China;Department of Urology, Xuzhou Medical College, 221000, Xuzhou, Jiangsu, China;

关键词: Neutrophil-to-lymphocyte ratio;    CD34;    Prostate cancer;    Microvessel density;   

DOI  :  10.1186/s12885-020-07382-3

来源: Springer

【 摘 要 】

BackgroundsThe association of neutrophil-lymphocyte ratio (NLR) and CD34 expression level with PSA level, Gleason score, and clinical stage was investigated in patients with prostate cancer. The correlation between NLR and CD34 expression was also investigated to provide evidence supporting the use of NLR for predicting the prognosis of prostate cancer patients.MethodsClinical data of 75 patients diagnosed with prostate cancer by prostate aspiration biopsy were retrospectively analyzed. The correlation between NLR, CD34 expression, and clinicopathological characteristics was analyzed using the χ2 test and one-way analysis of variance. The correlation between NLR and CD34 was determined using the Pearson coefficient. Disease free survival was estimated by Kaplan-Meier analysis.ResultsBoth NLR and CD34 expression were significantly positively correlated with PSA, Gleason score, and clinical stage (P < 0.05 both). Patients in the NLRHigh/CD34High group were characterized by high PSA level and Gleason score and late clinical stage. NLR was positively correlated with CD34 expression (r = 0.529, P < 0.001).ConclusionsPretreatment NLR was a valuable marker of prognosis in prostate cancer. NLR is positively correlated with CD34 expression.

【 授权许可】

CC BY