Exercise and colorectal cancer: a systematic review and meta-analysis of exercise safety, feasibility and effectiveness

International Journal of Behavioral Nutrition and Physical Activity

Sandra C. Hayes¹  Laurent Gergele²  Rosalind R. Spence³  Megan L. Steele⁴  Guillaume Y. Millet⁵  Benjamin Singh⁶ 

[1] Griffith University, Menzies Health Institute Queensland, Brisbane, Queensland, Australia;Hôpital Privé de la Loire, Saint-Étienne, France;Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Avenue, Kelvin Grove, Queensland, Australia;School of Clinical Medicine, University of Queensland, St. Lucia, Queensland, Australia;Univ Lyon, UJM-Saint-Etienne, Inter-university Laboratory of Human Movement Biology, EA 7424, F-42023, Saint-Etienne, France;Institut Universitaire de France (IUF), Paris, France;Univ Lyon, UJM-Saint-Etienne, Inter-university Laboratory of Human Movement Biology, EA 7424, F-42023, Saint-Etienne, France;Laboratoire Interuniversitaire de Biologie de la Motricité, Bâtiment IRMIS, 10 rue de la Marandière, 42270, Saint Priest en Jarez, France;

关键词: Colon;    Colorectal;    Rectal;    Cancer;    Neoplasm;    Aerobic exercise;    Resistance exercise;    Exercise oncology;   

DOI  :  10.1186/s12966-020-01021-7

来源: Springer

【 摘 要 】

BackgroundThis meta-analysis evaluated the safety, feasibility and effect of exercise among individuals with colorectal cancer.MethodsA database search (CINAHL, Ebscohost, MEDLINE, Pubmed, ProQuest Health and Medical Complete, ProQuest Nursing, Science Direct) for randomised, controlled, exercise trials involving individuals with colorectal cancer, published before January 1, 2020 was undertaken. Safety (adverse events), feasibility (withdrawal and adherence rates) and effect data (health outcomes including quality of life, QoL) were abstracted. Risk difference (RD) and standardised mean differences (SMD) were calculated to compare safety and effects between exercise and usual care (UC). Subgroup analyses were conducted to assess whether outcomes differed by exercise mode, duration, supervision and treatment. Risk of bias was assessed using the Physiotherapy Evidence Database tool.ResultsFor the 19 trials included, there was no difference in adverse event risk between exercise and UC (RD = 0.00; 95% CI:–0.01, 0.01, p = 0.92). Median withdrawal rate was 12% (0–22%) and adherence was 86% (42–91%). Significant effects of exercise compared to UC were observed for QoL, fatigue, aerobic fitness, upper-body strength, depression, sleep and reduced body fat (SMD = 0.21–0.66, p < 0.05). Subgroup analyses suggested larger benefits (p < 0.05) for QoL and fatigue for supervised interventions; for QoL, aerobic fitness and reduced body fat for ≥12-week interventions; and for aerobic fitness when interventions were during chemotherapy.ConclusionAlthough reporting of safety and compliance data was lacking in most trials, findings support that exercise is safe and feasible in colorectal cancer. Further, participation in mixed-mode exercise, including unsupervised exercise, leads to improvements in various health-related outcomes.

【 授权许可】

CC BY