Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy

Nano-Micro Letters

Shenghui Zeng¹  Xu Liu¹  Haishan Shi¹  Changren Zhou¹  Tao Yu¹  Renwen Zhang²  Guodong Sun³  Baocheng Wang⁴ 

[1] College of Chemistry and Material Sciences, Jinan University, 510632, Guangzhou, People’s Republic of China;College of Traditional Chinese Medicine, Jinan University, 510632, Guangzhou, People’s Republic of China;Department of Orthopedics, First Affiliated Hospital, Jinan University, 510632, Guangzhou, People’s Republic of China;Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, 518055, Shenzhen, People’s Republic of China;

关键词: Silica;    Drug delivery;    Spinal cord injury;    Arctigenin;    Astrocytes;   

DOI  :  10.1007/s40820-019-0252-6

来源: Springer

【 摘 要 】

tsWith good biocompatibility, a silica-based drug delivery system was prepared and used effectively in vivo to prolong the duration of drug treatment.The prepared system can target spinal cord injury directly. Additionally, due to its small size (approximately 100 nm), it can penetrate the blood-spinal cord barrier.This system reduced the expression of interleukin-17 (IL-17) and IL-17-related inflammatory factors and can protect neurons and promote the recovery of spinal cord injury.

【 授权许可】

CC BY