Chronic rhinosinusitis due to cyano-acrylic glue after endoscopic transsphenoidal pituitary surgery

BMC Surgery

Ala”a A. Alhowary¹  Abdelwahab J. Aleshawi²  Majid Bani-Ata³  Firas Alzoubi⁴  Bashar Abuzayed⁵ 

[1]Department of Anesthesia, Faculty of Medicine, Jordan University of Science and Technology, 22110, Irbid, Jordan

[2]Department of Special Surgery, Division of Ophthalmology, Faculty of Medicine, Jordan University of Science and Technology, 22110, Irbid, Jordan

[3]Department of Special Surgery, Division of Otolaryngology, Faculty of Medicine, Jordan University of Science and Technology, P.O.Box: 3030, 22110, Irbid, Jordan

[4]Department of otolaryngology, Faculty of Medicine, Jordan University of Science and Technology, 22110, Irbid, Jordan

[5]Gardens Hospital, P.O.Box: 4144, Al Sab Bin Jathamah St, Amman, Jordan

关键词: Acrylic glue;    Transsphenoidal approach;    Chronic rhinosinusitis;   

DOI  :  10.1186/s12893-020-00866-w

来源: Springer

【 摘 要 】

BackgroundTo reduce the risk of cerebrospinal fluid leak, clinicians utilize a filling material placed in the sella followed by floor reconstruction with various materials, including glue sealing. Cyano-acrylic glue Glubran®2 glue is commercially available and is generally used as embolizing agent and for the prevention of cerebrospinal fluid leakage.Case DescriptionA 25-year-old woman underwent endoscopic endonasal transsphenoidal surgery for pituitary adenoma. After tumor resection, sellar floor reconstruction was performed by mucosal graft and Glubran®2 glue. The early post-operative period was uneventful. However, 2 months after surgery, the patient complained of headache, facial pain and greenish foul-smelling nasal discharge with solid particles dripping from the nose. Medical treatment was unsuccessful. Brain MRI showed inflammation and thickening of the sphenoidal and para-sphenoidal mucosa. The patient underwent endoscopic endonasal surgery and a solid glass-like mass surrounded by inflamed infected mucosa was seen in the inferior and lateral aspects of the sphenoid sinus. Efforts were made to erupt and de-crust the solid mass until total resection was achieved. Early post-operative period was uneventful, and a course of antibiotics was continued until total disappearance of the discharge.ConclusionTo the best of our knowledge, this is the first case reporting of acrylic glue (Glubran®2)-related sinusitis. Surgeon should be aware about similar side effects for the glue material that would complicate the surgery.

【 授权许可】

CC BY