The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm

BMC Gastroenterology

Ryuichi Yoshida¹  Yuzo Umeda¹  Takahito Yagi¹  Yuki Fujii²  Hironari Kato²  Kazuya Miyamoto²  Tatsuhiro Yamazaki²  Daisuke Uchida²  Hiroyuki Okada²  Takeshi Tomoda²  Shigeru Horiguchi²  Yosuke Saragai²  Kazuyuki Matsumoto²  Akihiro Matsumi²  Hirohumi Inoue³  Takehiro Tanaka³ 

[1] Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama, Japan;Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, 2-5-1 Shikata-cho, 700-8558, Okayama, Japan;Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama, Japan;

关键词: IPMN;    PJC;    LBC;    BD SurePath;   

DOI  :  10.1186/s12876-020-01465-y

来源: Springer

【 摘 要 】

BackgroundPancreatic juice cytology (PJC) is a tool for diagnosing malignant intraductal papillary mucinous neoplasm (IPMN); however, the accuracy is insufficient using the conventional method. Liquid-based cytology (LBC) improves the cell recovery rate, and almost all cells can be evaluated. We evaluated the efficacy of PJC with LBC for malignant IPMN.MethodsWe retrospectively analyzed 90 patients with suspected malignant IPMN who underwent PJC before pancreatectomy. PJC with smear and LBC methods was conducted in 52 patients (between June 2003 to December 2011) and 38 patients (between January 2012 to December 2018). Based on the imaging studies, all of the patients were classified according to the international consensus guidelines for IPMN revised in 2017.ResultsOf the 90 patients, 43 (48%) had malignant IPMN (high-grade dysplasia or invasive carcinoma), and the remaining patients had non-malignant IPMN (intermediate- or low-grade dysplasia). LBC increased the accuracy of PJC for the diagnosis of malignant IPMN (smear method: 56% [29/52] vs. LBC method: 76% [29/38]; P = 0.044). In a multivariate analysis, LBC was a significant factor influencing the accurate diagnosis of PJC (odds ratio: 3.52; P = 0.021). Furthermore, LBC increased the accuracy of PJC for malignant IPMN in patients with worrisome features (smear method: 66% [19/29] vs. LBC method: 93% [14/15]; P = 0.043).ConclusionsLBC increases the accuracy of PJC for diagnosing malignant IPMN compared with the conventional smear method.

【 授权许可】

CC BY