BMC Veterinary Research | |
Assessment of a biofluid mechanics-based model for calculating portal pressure in canines | |
Long-Ci Sun1  Jia-Yun Lin2  Chi-Hao Zhang2  Yi-Ming Zhu2  Lei Zheng2  Meng Luo2  Wen-Sheng Deng2  Chen-Lu Song3  Li-Zhong Wu4  Li Zheng5  | |
[1] Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No.160 Pujian Road, 200127, Shanghai, China;Department of General Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639 Zhizaoju Road, 200011, Shanghai, China;Department of Plastic Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639 Zhizaoju Road, 200011, Shanghai, China;Department of Radiation, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639 Zhizaoju Road, 200011, Shanghai, China;Department of Ultrasound, Shanghai Baoshan Integrated Traditional Chinese and Western Medicine Hospital, No. 181 Youyi Road, 201900, Shanghai, China; | |
关键词: Biofluid mechanics; Non-invasive; Portal hypertension; Portal pressure; | |
DOI : 10.1186/s12917-020-02478-1 | |
来源: Springer | |
【 摘 要 】
BackgroundPortal hypertension is a severe complication caused by various chronic liver diseases. The standard methods for detecting portal hypertension (hepatic venous pressure gradient and free portal pressure) are available in only a few hospitals due to their technical difficulty and invasiveness; thus, non-invasive measuring methods are needed. This study aimed to establish and assess a novel model to calculate free portal pressure based on biofluid mechanics.ResultComparison of each dog’s virtual and actual free portal pressure showed that a biofluid mechanics-based model could accurately predict free portal pressure (mean difference: -0.220, 95% CI: − 0.738 to 0.298; upper limit of agreement: 2.24, 95% CI: 1.34 to 3.14; lower limit of agreement: -2.68, 95% CI: − 3.58 to − 1.78; intraclass correlation coefficient: 0.98, 95% CI: 0.96 to 0.99; concordance correlation coefficient: 0.97, 95% CI: 0.93 to 0.99) and had a high AUC (0.984, 95% CI: 0.834 to 1.000), sensitivity (92.3, 95% CI: 64.0 to 99.8), specificity (91.7, 95% CI: 61.5 to 99.8), positive likelihood ratio (11.1, 95% CI: 1.7 to 72.8), and low negative likelihood ratio (0.08, 95% CI: 0.01 to 0.6) for detecting portal hypertension.ConclusionsOur study suggests that the biofluid mechanics-based model was able to accurately predict free portal pressure and detect portal hypertension in canines. With further research and validation, this model might be applicable for calculating human portal pressure, detecting portal hypertensive patients, and evaluating disease progression and treatment efficacy.
【 授权许可】
CC BY
【 预 览 】
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RO202104240283482ZK.pdf | 2647KB | download |