Using self-collection HPV testing to increase engagement in cervical cancer screening programs in rural Guatemala: a longitudinal analysis

BMC Public Health

Gina Ogilvie¹  Kristin Bevilacqua²  Rafael Meza²  Ergest Isak²  Audrey R. Murchland²  Christian S. Alvarez³  Anna Gottschlich⁴  Mark Prince⁵  Thomas E. Carey⁶  Alvaro Rivera-Andrade⁷  Carlos Mendoza-Montano⁷  Michael Dean⁸ 

[1] Clinical Prevention Services, BC Centre for Disease Control, Vancouver, BC, Canada;Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA;Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA;Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA;Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA;Vancouver, Canada;Department of Otolaryngology, University of Michigan, Ann Arbor, MI, USA;Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA;Department of Otolaryngology, University of Michigan, Ann Arbor, MI, USA;Institute of Nutrition of Central America and Panama-INCAP, Guatemala City, Guatemala;Laboratory of Translational Genomics, Division of Cancer, Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MD, USA;

关键词: Cervical cancer;    Human papillomavirus;    Self-collection;    Indigenous populations;   

DOI  :  10.1186/s12889-020-09478-8

来源: Springer

【 摘 要 】

BackgroundCervical cancer is a leading cause of death in low- and middle-income countries. Self-collection testing for human papillomavirus (HPV) is an alternative form of cervical cancer screening that can be completed privately and at home. Understanding how the use of HPV testing influences follow-up care in low-resourced settings is crucial before broad implementation. This study aimed to identify if access to self-collection HPV testing impacts participation in established cervical cancer screening programs among women in two rural communities in Guatemala.MethodsA cohort of 956 women was recruited in 2016 and followed for 2 years for the HPV Multiethnic Study (HPV MES). At baseline, women answered a questionnaire assessing cervical cancer screening history and were offered self-collection HPV testing. Women were re-contacted yearly to determine receipt of additional screening. Statistical changes in screening behavior before and throughout study participation, stratified by self-collection status, were assessed using McNemar pair tests for proportions. Alluvial plots were constructed to depict changes in individual screening behavior. The odds of changes in Pap-compliance (screened in past 3 years), given collection status, were assessed using multivariate logistic regressions.ResultsReported screening rates increased 2 years after enrollment compared to rates reported for the 3 years before study entry among women who collected a sample (19.1% increase, p < 0.05), received results of their test (22.1% increase, p < 0.05), and received positive (24.2% increase, p < 0.1) or negative results (21.7% increase, p < 0.05). However, most increases came from one community, with minimal changes in the other. The adjusted odds of becoming Pap compliant were higher for women who collected a sample vs. did not (OR: 1.48, 95% CI: 0.64, 3.40), received their result vs. did not (OR: 1.29, 95% CI: 0.52, 3.02), and received a positive result vs. negative (OR: 2.43, 95% CI: 0.63, 16.10).ConclusionsParticipation in self-collection HPV testing campaigns may increase likelihood of involvement in screening programs. However, results varied between communities, and reporting of screening histories was inconsistent. Future work should identify what community-specific factors promote success in HPV testing programs and focus on improving education on existing cervical cancer interventions.

【 授权许可】

CC BY