No difference in leprosy treatment outcomes comparing 12- and 24-dose multidrug regimens: a preliminary study

Cadernos de Saúde Pública

Anna Maria Sales²  Paulo Chagastelles Sabroza¹  José Augusto Da Costa Nery²  Nádia Cristina Dupprè²  Euzenir Nunes Sarno² 

[1] ,Fundação Oswaldo Cruz Instituto Oswaldo Cruz Rio de Janeiro,Brasil

关键词: Leprosy;    Drug Therapy;    Comparative Study;    Hanseníase;    Quimioterapia;    Estudo Comparativo;   

DOI  :  10.1590/S0102-311X2007000400009

来源: SciELO

【 摘 要 】

A comparative study was performed on the initial and final bacillary indexes of 213 multibacillary leprosy patients who received 12 doses (Group 1: 128 patients) or 24 doses (Group 2: 85 patients) of multidrug therapy (MDT/WHO) to measure the effectiveness of the two regimens. All patients were evaluated at treatment baseline, 12 months, and 24 months. The reduction in bacillary levels and mean bacillary indexes at 24 months was similar in the two groups. No statistical difference in reaction rates was observed between the two treatment regimens.

【 授权许可】

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