Organochlorine exposure and breast cancer risk in Colombian women

Cadernos de Saúde Pública

P. Olaya-contreras²  J. Rodríguez-villamil¹  H. J. Posso-valencia¹  J. E. Cortez¹ 

[1] ,Instituto Nacional de Salud Pública de México Centro de Salud Poblacional Cuernavaca Morelos ,México

关键词: Breast Neoplasms;    Environmental Exposure;    Pesticide Exposure;    Logistic Regression;    Case-Control Studies;    Neoplasias Mamárias;    Exposição Ambiental;    Exposição a Praguicidas;    Regressão Logística;    Estudos de Casos e Controles;   

DOI  :  10.1590/S0102-311X1998000700013

来源: SciELO

【 摘 要 】

An epidemiological study was performed in Santafé de Bogotá, Colombia, with a total of 306 women enrolled, including 153 incident BC cases and 153 age-matched controls. The objective of this study was to evaluate the association between BC risk and serum dichlorodiphenyl-dichloroethene (DDE) levels. Sociodemographic and reproductive data, diet, and past exposure to pesticides were obtained through a structured questionnaire. Chemical analysis of samples was performed by high resolution gas chromatography-ECD. Likelihood of developing BC by exposure to these substances was evaluated through odds ratios (OR) adjusted for: first-child breast-feeding, family BC history, body mass index (BMI), parity, and menopausal status. Data analysis was performed by conditional logistic regression techniques. Adjusted OR for exposure to serum DDE and BC suggests an increase risk of BC in the higher category of DDE exposure (OR = 1.95; CI 1.10-3.52). The test for trend was not statistically significant (p = 0.09). We confirm that serum DDE levels bear a positive association to risk of BC and could support the association between risk of BC and burden of DDE exposure.

【 授权许可】

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