Novel neurotherapeutics in psychiatry: use and rationale of transcranial direct current stimulation in major depressive disorder

Archives of Clinical Psychiatry (São Paulo)

Adriano H. Moffa¹  Leandro Valiengo¹  Pedro Shiozawa¹  André Russowsky Brunoni¹ 

关键词: Transcranial direct current stimulation;    major depressive disorder;    systematic review;    non invasive neuromodulation;    interventional psychiatry;    neurotherapeutics;    Estimulação transcraniana por corrente contínua;    transtorno depressivo maior;    revisão sistemática;    neuromodulação não invasiva;    psiquiatria intervencionista;    neuroterapêuticas;   

DOI  :  10.1590/0101-60830004111520

来源: SciELO

【 摘 要 】

Background: Transcranial direct current stimulation (tDCS) is a novel non-pharmacological intervention being investigated for the treatment of major depressive disorder (MDD). Objective: To perform an updated review of tDCS for MDD. Method: Systematic review in Medline/PubMed and other databases of all clinical studies evaluating the clinical efficacy of tDCS in MDD, from the first date available to December/2013. Results: Out of 55 articles, 24 were included, being 6 open-label studies; 8 randomized, double-blind, sham-controlled trials; 2 follow-up studies; 2 meta-analyses and 6 case reports. We observed an improvement of 20-40% in depressive symptoms, being slightly better in open studies. Five randomized clinical trials displayed positive results. The meta-analyses presented mixed results; although none included the study of Brunoni et al. (2013) that represents almost 50% of the evaluated sample. Open-label studies and case reports also investigated tDCS in bipolar depression, post-stroke depression and employed different parameters of stimulation. Discussion: TDCS is a novel, promising treatment for MDD. Definite evidence from large, ongoing clinical trials will be available in the next years.

【 授权许可】

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