BK polyomavirus in Kidney transplant recipients: screening, monitoring and clinical management

Jornal Brasileiro de Nefrologia

Rafael Brandão Varella¹  Jorge Reis Almeida¹  Patrícia De Fátima Lopes¹  Jorge Paulo Strogoff De Matos¹  Paulo Menezes¹  Jocemir Ronaldo Lugon¹ 

关键词: infection control;    kidney transplantation;    monitoring;    review;    controle de infecções;    monitoramento;    revisão;    transplante de rim;   

DOI  :  10.5935/0101-2800.20140075

来源: SciELO

【 摘 要 】

BK polyomavirus (BKPyV) is a causal agent of nephropathy, ureteral stenosis and hemorrhagic cystitis in kidney transplant recipients, and is considered an important emerging disease in transplantation. Regular screening for BKPyV reactivation mainly during the first 2 years posttransplant, with subsequent pre-emptive reduction of immunosuppression is considered the best option to avoid disease progression, since successful clearance or reduction of viremia is achieved in the vast majority of patients within 6 months. The use of drugs with antiviral properties for patients with persistent viremia has been attempted despite unclear benefits. Clinical manifestations of BKPyV nephropathy, current strategies for diagnosis and monitoring of BKPyV infection, management of immunosuppressive regimen after detection of BKPyV reactivation and the use of antiviral drugs are discussed in this review.

【 授权许可】

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