Experimental models in vaccine research: malaria and leishmaniasis

Brazilian Journal of Medical and Biological Research

C. Teixeira¹  R. Gomes¹ 

关键词: Human vaccines;    Animal models;    Malaria;    Leishmaniasis;   

DOI  :  10.1590/1414-431X20122460

来源: SciELO

【 摘 要 】

Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License