Focal adhesion kinase signaling in cardiac hypertrophy and failure

Brazilian Journal of Medical and Biological Research

K.g. Franchini¹  C.f.m.z. Clemente¹  T.m. Marin¹ 

[1] ,Universidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de Clínica MédicaCampinas SP ,Brasil

关键词: Focal adhesion kinase;    Mechanical signaling;    Cardiovascular system;    Signal transduction;   

DOI  :  10.1590/S0100-879X2009000100008

来源: SciELO

【 摘 要 】

Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.

【 授权许可】

CC BY   
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