Nuclear calcium signaling: a cell within a cell

Brazilian Journal of Medical and Biological Research

M.a. Rodrigues²  D.a. Gomes¹  M.h. Nathanson¹  M.f. Leite² 

[1] ,Universidade Federal de Minas Gerais Departamento de Fisiologia e Biofísica Belo Horizonte MG ,Brasil

关键词: Calcium;    Proliferation;    Receptor tyrosine kinases;    Nucleus;   

DOI  :  10.1590/S0100-879X2008005000050

来源: SciELO

【 摘 要 】

Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate formation within the nucleus rather than within the cytoplasm. This novel signaling mechanism may be responsible for growth factor effects on cell proliferation.

【 授权许可】

CC BY   
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