Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients

Brazilian Journal of Medical and Biological Research

B.t. Costa-carvalho²  R.m.a. Martinez²  A.t.n. Dias¹  C.a. Kubo¹  P. Barros-nunes²  L. Leiva¹  D. Solé²  M.m.s. Carneiro-sampaio¹  C.k. Naspitz²  R.u. Sorensen¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina Departamento de PediatriaSão Paulo SP ,Brasil

关键词: Down syndrome;    Immunoglobulin;    IgG subclass;    Polysaccharide vaccine;    Streptococcus pneumoniae;    Pneumococcal antibodies;   

DOI  :  10.1590/S0100-879X2006005000047

来源: SciELO

【 摘 要 】

The majority of children with Down syndrome (DS) tend to have frequent bacterial infections including recurrent respiratory infections. Our objective was to evaluate the production of antibodies to pneumococcal polysaccharide antigens after active immunization in DS subjects. IgG antibodies to pneumococcal serotypes (1, 3, 6B, 9V, and 14) were measured before and 6 weeks after immunization with a 23-valent pneumococcal vaccine (Pneumo23®, Pasteur-Merrieux) in 6- to 13-year-old DS children (N = 17) and in aged-matched normal controls (N = 30). An adequate response was defined as a 4-fold increase over baseline or a post-immunization level of specific pneumococcal serotype antibody> or = 1.3 µg/mL. After immunization, all DS children had an increase in post-immunization levels against all serotypes analyzed. A 4-fold or more increase was observed in all DS children concerning serotypes 1 and 14, in 90% of subjects for serotypes 3 and 9V, and in 65% for serotype 6B. Regarding this increase, 8 of the 17 DS children had an adequate response to all serotypes analyzed, 8/17 patients to 4 serotypes and 1/17 to 3 serotypes. However, when we compared post-immunization levels between DS children and controls, we observed lower levels in the former group (P < 0.05) for all serotypes except serotype 3. We conclude that pneumococcal polysaccharide immunization could be beneficial for these DS children.

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