Frequency of CCR5delta32 in Brazilian populations

Brazilian Journal of Medical and Biological Research

A.e. Vargas¹  A.r. Marrero¹  F.m. Salzano¹  M.c. Bortolini¹  J.a.b. Chies¹ 

[1] ,Universidade Federal do Rio Grande do Sul Instituto de Biociências Departamento de GenéticaPorto Alegre RS ,Brasil

关键词: CCR5;    Chemokine receptors;    Brazilian population;    Gene flow;   

DOI  :  10.1590/S0100-879X2006000300002

来源: SciELO

【 摘 要 】

A sample of 103 randomly chosen healthy individuals from Alegrete, RS, Brazil, was tested for the CCR5delta32 allele, which is known to influence susceptibility to HIV-1 infection. The CCR5delta32 allele was identified by PCR amplification using specific primers flanking the region of deletion, followed by electrophoresis on a 3% agarose gel. The data obtained were compared to those reported for other populations and interpreted in terms of Brazilian history. The individuals studied came from a highly admixed population. Most of them were identified as white (N = 59), while blacks and browns (mulattoes) were N = 13 and N = 31, respectively. The observed frequencies, considering the white, black and brown samples (6.8, 3.8, and 6.4%, respectively), suggest an important European parental contribution, even in populations identified as black and brown. However, in Brazil as a whole, this allele shows gradients indicating a relatively good correlation with the classification based on skin color and other physical traits, used here to define major Brazilian population groups.

【 授权许可】

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