Brazilian Journal of Medical and Biological Research | |
Molecular biology and clinical implication of hepatitis C virus | |
A.c. Lyra1  X. Fan1  A.m. Di Bisceglie1  | |
关键词: Hepatitis C; Molecular biology; Quasispecies; | |
DOI : 10.1590/S0100-879X2004000500010 | |
来源: SciELO | |
【 摘 要 】
Hepatitis C virus (HCV) was first described in 1989 as the putative viral agent of non-A non-B hepatitis. It is a member of the Flaviviridae family and has been recognized as the major causative agent of chronic liver disease, including chronic active hepatitis, cirrhosis and hepatocellular carcinoma. HCV is a positive RNA virus with a genome containing approximately 9500 nucleotides. It has an open reading frame that encodes a large polyprotein of about 3000 amino acids and is characterized by extensive genetic diversity. HCV has been classified into at least 6 major genotypes with many subtypes and circulates within an infected individual as a number of closely related but distinct variants known as quasispecies. This article reviews aspects of the molecular biology of HCV and their clinical implication.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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RO202103040077333ZK.pdf | 487KB | download |