Effect of dietary linoleic acid on the progression of chronic renal failure in rats

Brazilian Journal of Medical and Biological Research

S.m.p. Gregório¹  C.c.s. Lemos²  M.l. Caldas¹  R. Bregman² 

[1] ,Universidade Estadual do Rio de Janeiro Divisão de Nefrologia Rio de Janeiro RJ ,Brasil

关键词: Chronic kidney failure;    Diet;    Glomeruli;    Linoleic acid;   

DOI  :  10.1590/S0100-879X2002000500010

来源: SciELO

【 摘 要 】

The role of linoleic acid in chronic renal failure (CRF) is controversial. In the present study 21 male Wistar rats submitted to 5/6 renal mass reduction (R) and 16 normal controls (C) were fed a supplement (S) or normal (N) linoleic acid diet for 60 days starting 10 days after CRF. As expected, serum creatinine, cholesterol and triglycerides (mean ± SEM) were higher in the CRF groups compared to the C groups (P<0.05). The RS group presented lower cholesterol (84 ± 4 vs 126 ± 13 mg%) and triglyceride (88 ± 9 vs 132 ± 19 mg%) levels compared to the RN group. Proteinuria and kidney weight did not differ between CRF groups. Glomerular area increased 78% in RS and 100% in RN compared to control rats. Glomerular sclerosis index tended to be lower in RS (27%) compared to RN (38%), tubulointerstitial damage was similar between CRF groups (RS = 1.91 ± 0.2 and RN = 2.14 ± 0.3), and mesangial fractional volume increased to the same extent in both CRF groups. The data suggest that a linoleic acid-enriched diet did not protect against the progression of CRF after 60 days.

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