Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice

Brazilian Journal of Medical and Biological Research

C.m.t. Queiroz¹  F.b. Alcântara¹  A.m.l. Yagüe¹  T. Bibancos¹  R. Frussa-filho¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina Departamento de FarmacologiaSão Paulo SP ,Brasil

关键词: Buspirone;    Haloperidol;    Dopaminergic supersensitivity;    Tardive dyskinesia;    Behavior;    Mice;   

DOI  :  10.1590/S0100-879X2002000200013

来源: SciELO

【 摘 要 】

Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-benzodiazepine anxiolytic buspirone attenuates the development of haloperidol-induced dopaminergic supersensitivity measured by open-field behavior of rats. The aims of the present study were: 1) to determine, as previously reported for rats, if mice withdrawn from long-term neuroleptic treatment would also develop dopaminergic supersensitivity using open-field behavior as an experimental paradigm, and 2) to examine if acute buspirone administration would attenuate the expression of this behavioral dopaminergic supersensitivity. Withdrawal from long-term haloperidol treatment (2.5 mg/kg, once daily, for 20 days) induced a significant (30%) increase in ambulation frequency (i.e., number of squares crossed in 5-min observation sessions) but did not modify rearing frequency or immobility duration in 3-month-old EPM-M1 male mice observed in the open-field apparatus. Acute intraperitoneal injection of buspirone (3.0 and 10 but not 1.0 mg/kg, 12-13 animals per group) 30 min before open-field exposure abolished the increase in locomotion frequency induced by haloperidol withdrawal. These data suggest that the open-field behavior of mice can be used to detect dopaminergic supersensitivity, whose expression is abolished by acute buspirone administration.

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