期刊论文详细信息
Brazilian Journal of Medical and Biological Research
Reporting on methods of subgroup analysis in clinical trials: a survey of four scientific journals
E.d. Moreira Jr.2  Z. Stein1  E. Susser1 
[1] ,Fundação Oswaldo Cruz Centro de Pesquisas Gonçalo Moniz Núcleo de Epidemiologia e EstatísticaSalvador BA ,Brasil
关键词: subgroup analyses;    randomized clinical trials;    research design;    epidemiological methods;    effect modification;   
DOI  :  10.1590/S0100-879X2001001100011
来源: SciELO
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【 摘 要 】

Results of subgroup analysis (SA) reported in randomized clinical trials (RCT) cannot be adequately interpreted without information about the methods used in the study design and the data analysis. Our aim was to show how often inaccurate or incomplete reports occur. First, we selected eight methodological aspects of SA on the basis of their importance to a reader in determining the confidence that should be placed in the author's conclusions regarding such analysis. Then, we reviewed the current practice of reporting these methodological aspects of SA in clinical trials in four leading journals, i.e., the New England Journal of Medicine, the Journal of the American Medical Association, the Lancet, and the American Journal of Public Health. Eight consecutive reports from each journal published after July 1, 1998 were included. Of the 32 trials surveyed, 17 (53%) had at least one SA. Overall, the proportion of RCT reporting a particular methodological aspect ranged from 23 to 94%. Information on whether the SA preceded/followed the analysis was reported in only 7 (41%) of the studies. Of the total possible number of items to be reported, NEJM, JAMA, Lancet and AJPH clearly mentioned 59, 67, 58 and 72%, respectively. We conclude that current reporting of SA in RCT is incomplete and inaccurate. The results of such SA may have harmful effects on treatment recommendations if accepted without judicious scrutiny. We recommend that editors improve the reporting of SA in RCT by giving authors a list of the important items to be reported.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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