Regulation of the renal proximal tubule second sodium pump by angiotensins

Brazilian Journal of Medical and Biological Research

C. Caruso-neves¹  L.b.a. Rangel¹  L.s. Lara¹  A.g. Lopes¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho Rio de Janeiro RJ ,Brasil

关键词: Na+-ATPase;    angiotensin II;    angiotensin-(1-7);    furosemide;    proximal tubule;   

DOI  :  10.1590/S0100-879X2001000800015

来源: SciELO

【 摘 要 】

For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption.

【 授权许可】

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