RNA and DNA aptamers as potential tools to prevent cell adhesion in disease

Brazilian Journal of Medical and Biological Research

H. Ulrich¹  M.j.m. Alves¹  W. Colli¹ 

[1] ,Universidade de São Paulo Instituto de Química Departamento de BioquímicaSão Paulo SP ,Brasil

关键词: SELEX;    aptamers;    cell adhesion;    cell invasion;    Trypanosoma cruzi;   

DOI  :  10.1590/S0100-879X2001000300002

来源: SciELO

【 摘 要 】

Recent research has shown that receptor-ligand interactions between surfaces of communicating cells are necessary prerequisites for cell proliferation, cell differentiation and immune defense. Cell-adhesion events have also been proposed for pathological conditions such as cancer growth, metastasis, and host-cell invasion by parasites such as Trypanosoma cruzi. RNA and DNA aptamers (aptus = Latin, fit) that have been selected from combinatorial nucleic acid libraries are capable of binding to cell-adhesion receptors leading to a halt in cellular processes induced by outside signals as a consequence of blockage of receptor-ligand interactions. We outline here a novel approach using RNA aptamers that bind to T. cruzi receptors and interrupt host-cell invasion in analogy to existing procedures of blocking selectin adhesion and function in vitro and in vivo.

【 授权许可】

CC BY   
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