How are antibodies involved in the protective mechanism of susceptible mice infected with T. cruzi?

Brazilian Journal of Medical and Biological Research

L.f. Umekita¹  I. Mota¹ 

[1] ,Instituto ButantanSão Paulo SP ,Brasil

关键词: Trypanosoma cruzi;    chronic mouse antibodies;    clearance;    cytokines;    acute phase;    susceptible mice;   

DOI  :  10.1590/S0100-879X2000000300001

来源: SciELO

【 摘 要 】

Host resistance to Trypanosoma cruzi is dependent on both natural and acquired immune responses. During the acute phase of the infection the presence of IFN-g, TNF-a, IL-12 and GM-CSF has been closely associated with resistance, whereas TGF-ß and IL-10 have been associated with susceptibility. Several investigators have demonstrated that antibodies are responsible for the survival of susceptible animals in the initial phase of infection and for the maintenance of low levels of parasitemia in the chronic phase. However, how this occurs is not yet understood. Our results and other data in the literature support the hypothesis that the protective role of antibodies in the acute phase of infection is dependent mostly on their ability to induce removal of bloodstream trypomastigotes from the circulation in addition to other concomitant cell-mediated events.

【 授权许可】

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