Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH

Brazilian Journal of Medical and Biological Research

H.a. Armelin¹  C.f.p. Lotfi¹ 

[1] ,Universidade de São PauloSão Paulo SP ,Brasil

关键词: adrenocortical cell cycle;    ACTH;    FGF2;    ERK-MAPK;    c-fos proto-oncogene;   

DOI  :  10.1590/S0100-879X1999000700007

来源: SciELO

【 摘 要 】

FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.

【 授权许可】

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