Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection

Brazilian Journal of Medical and Biological Research

F. Costa¹  V.l. Pereira-chioccola¹  M. Ribeirão¹  S. Schenkman¹  M.m. Rodrigues¹ 

[1] ,Universidade Federal de São Paulo

关键词: DNA vaccination;    Trans-sialidase;    Chagas' disease;   

DOI  :  10.1590/S0100-879X1999000200013

来源: SciELO

【 摘 要 】

Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License