Endogenous vasopressin and the central control of heart rate during dynamic exercise

Brazilian Journal of Medical and Biological Research

L.c. Michelini¹ 

[1] ,Universidade de São Paulo

关键词: exercise tachycardia;    V1 receptors;    brainstem areas;    peptides;    blood pressure;    training;    rats;   

DOI  :  10.1590/S0100-879X1998000900012

来源: SciELO

【 摘 要 】

The present article contains a brief review on the role of vasopressinergic projections to the nucleus tractus solitarii in the genesis of reflex bradycardia and in the modulation of heart rate control during exercise. The effects of vasopressin on exercise tachycardia are discussed on the basis of both the endogenous peptide content changes and the heart rate response changes observed during running in sedentary and trained rats. Dynamic exercise caused a specific vasopressin content increase in dorsal and ventral brainstem areas. In accordance, rats pretreated with the peptide or the V1 blocker into the nucleus tractus solitarii showed a significant potentiation or a marked blunting of the exercise tachycardia, respectively, without any change in the pressure response to exercise. It is proposed that the long-descending vasopressinergic pathway to the nucleus tractus solitarii serves as one link between the two main neural controllers of circulation, i.e., the central command and feedback control mechanisms driven by the peripheral receptors. Therefore, vasopressinergic input could contribute to the adjustment of heart rate response (and cardiac output) to the circulatory demand during exercise.

【 授权许可】

CC BY   
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