Cytokines in innate and acquired immunity to Trypanosoma cruzi infection

Brazilian Journal of Medical and Biological Research

I.a. Abrahamsohn¹ 

[1] ,Universidade de São Paulo

关键词: Trypanosoma cruzi;    interferon-gamma;    interleukin-12;    TNF-alpha;    interleukin-10;    innate immunity;    knock-out mice;   

DOI  :  10.1590/S0100-879X1998000100015

来源: SciELO

【 摘 要 】

Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-a, IFN-g and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-g and TNF-a in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed

【 授权许可】

CC BY   
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