Decreased expression of cardiac troponin C is associated with cardiac lesions in Amorimia exotropica poisoned cattle

Pesquisa Veterinária Brasileira

Saulo Petinatti Pavarini¹  Marcele Bettim Bandinelli¹  Gregory Duarte Juffo¹  Suyene Oltramari De Souza¹  David Driemeier¹  Cláudio Estêvão Farias Da Cruz¹ 

[1] ,Universidade Federal do Rio Grande do Sul Faculdade de Veterinária Departamento de Patologia Clínica VeterináriaPorto Alegre RS ,Brazil

关键词: Amorimia exotropica;    cattle;    sudden death;    troponin;    immunohistochemistry;    cardiac injury;    Amorimia exotropica;    bovinos;    morte súbita;    troponina;    imuno-histoquímica;    lesão cardíaca;   

DOI  :  10.1590/S0100-736X2012001000010

来源: SciELO

【 摘 要 】

The plants which cause sudden death of cattle in Brazil occupy a leading position for losses in the cattle industry. Amorimia exotropica is one of the plants pertaining to this group. Diagnostic findings in these cases may be inconclusive; further knowledge is necessary. This paper identifies cardiac lesions through anti-cardiac troponin C (cTnC) immunehistochemistry performed in tissues from cattle poisoned after consumption of A.exotropica in southern Brazil. Heart fragments from nine A. exotropica-poisoned cattle were studied immunohistochemically using anti-human cTnC as the primary antibody. In the hearts from all of the poisoned cattle, there was a sharp decrease in the cTnC expression level in the cytoplasm of groups of cardiomyocytes. A significant decrease in anti-cTnC immunoreactivity occurred particularly in degenerated or necrotic cardiomyocytes. Occasional groups of cells showed complete loss of immunolabeling. In the remaining intact cardiomyocytes from poisoned cattle and in cardiomyocytes from six cattle that died from other causes there was intense cytoplasmic staining.

【 授权许可】

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