Morfometria das fibras colágeno cardíaco em ratos sadios e diabéticos suplementados com vitamina C

Pesquisa Veterinária Brasileira

Thiago Guerra Diniz²  Hildebrando Gomes Benedicto¹  Fernanda Rodrigues Agreste¹  Naianne Kelly Clebis¹  Francisco Javier Hernandez-blazquez¹  Pedro Primo Bombonato¹ 

[1],Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de CirurgiaSão Paulo SP ,Brasil

关键词: Heart;    collagen;    Diabetes mellitus;    vitamin C;    Coração;    colágeno;    Diabetes mellitus;    vitamina C;   

DOI  :  10.1590/S0100-736X2011001300001

来源: SciELO

【 摘 要 】

The increase of heart collagen fibers in diabetics is a well known fact, but the consequences are not defined. The aim was to quantify the cardiac collagen fibers in normal and diabetic rats treated with vitamin C. We selected 32 Wistar rats, 16 diabetic animals induced endovenously with streptozootocin, and 16 healthy animals, half of them, diabetics and normals, were treated with vitamin C for 90 days. After the experimental proceeding, the hearts were removed and processed accordingly to conventional protocol for optical microscopy and specific staining for collagen. The results showed that the diabetic rats presented increase in the number of cardiac collagen fibers, but the ones treated with vitamin C showed little accumulation of fibers. It could be concluded that treatment with vitamin C is important for the prevention of heart failure in diabetic animals.

【 授权许可】

CC BY-NC   
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