Aspectos clínico-patológicos da intoxicação experimental por selenito de sódio em eqüinos

Pesquisa Veterinária Brasileira

Pedro Brandini Néspoli²  Marcos Dutra Duarte¹  Pedro Soares Bezerra Jr¹  Jürgen Döbereiner¹  Paulo Vargas Peixoto¹ 

[1] ,Universidade Federal de Mato Grosso Departamento Clínica Médica Veterinária Cuiabá MT

关键词: Selenium;    sodium selenite;    poisoning;    horses;    clinics;    pathology;    Selênio;    selenito de sódio;    intoxicação;    eqüinos;    clínica;    patologia;   

DOI  :  10.1590/S0100-736X2001000300003

来源: SciELO

【 摘 要 】

Due to the numerous contradictions on selenium poisoining, and in order to improve knowledge about the clinical, pathological and toxicological aspects, experiments were performed with intramuscular injections of sodium selenite in 9 horses. Peracute, acute, subacute and chronic poisoning was reproduced; some nervous symptoms observed in acute cases were similar to those described for "blind staggers". In spite of this, the conflicting and dubious feature of this formerly described disease turns very difficult any comparison. On the other hand, the chronic poisoning was the first experimental reproduction of "alkali disease" by the parenteral route in horses. When administered as one injection, the lethal dose for sodium selenite was 1.49 mg/kg. Various clinical and pathological observations regarding the cardiovascular and nervous system, not previously mentioned in the literature for horses, are described. There have to be mentioned especially, (1) as to clinical aspects, cardiac murmurs, arrythmia, splitting of the heart sounds and convulsions, (2) regarding post-mortem findings, flattening of the cerebral gyri and increase of the liquor, and (3) concerning histopathology, lysis and necrosis of neurons in the cortex, oedema of astrocytes, as well as activation of endothelial and glia cells. It is suggested, that the degenerative-necrotic alterations in the central nervous system could be due to the oedema caused by an increase in vascular permeability through the action of the selenite.

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