Reference range of uterine artery Doppler parameters between the 11th and 14th pregnancy weeks in a population sample from Northeast Brazil

Revista Brasileira de Ginecologia e Obstetrícia

Júlio Augusto Gurgel Alves²  Bruna Yang Da Costa Silva¹  Paulo Cesar Praciano De Sousa²  Sammya Bezerra Maia²  Fabrício Da Silva Costa² 

[1] ,Universidade Estadual do Ceará Department of Public Health Fortaleza CE ,Brazil

关键词: Ultrasonography;    Doppler;    Pregnancy trimester;    first;    Pre-eclampsia;    Fetal growth retardation;    Placental circulation;    Ultrassonografia Doppler;    Primeiro trimestre de gravidez;    Pré-eclâmpsia;    Retardo do crescimento fetal;    Circulação placentária;   

DOI  :  10.1590/S0100-72032013000800004

来源: SciELO

【 摘 要 】

PURPOSE: To establish reference values for the first trimester uterine artery resistance index (UtA-RI) and pulsatility index (UtA-PI) in healthy singleton pregnant women from Northeast Brazil. METHODS: A prospective observational cohort study including 409 consecutive singleton pregnancies undergoing routine early ultrasound screening at 11 - 14 weeks of gestation was performed. The patients responded to a questionnaire to assess maternal epidemiological characteristics. The left and right UtA-PI and UtA-RI were examined by color and pulsed Doppler by transabdominal technique and the mean UtA-PI, mean UtA-RI and the presence of bilateral protodiastolic notching were recorded. Quartile regression was used to estimate reference values. RESULTS: The mean±standard deviation UtA-RI and UtA-PI were 0.7±0.1 and 1.5±0.5, respectively. When segregated for gestation age, mean UtA-PI was 1.6±0.5 at 11 weeks, 1.5±0.6 at 12 weeks, 1.4±0.4 at 13 weeks and 1.3±0.4 at 14 weeks' gestation and mean UtA-RI was 0.7±0.1 at 11 weeks, 0.7±0.1 at 12 weeks, 0.6±0.1 at 13 weeks and 0.6±0.1 at 14 weeks' gestation. Uterine artery bilateral notch was present in 261 (63.8%) patients. We observed that the 5th and 95th percentiles of the UtA-PI and UtA-RI uterine arteries were 0.7 and 2.3 and, 0.5 and 0.8, respectively. CONCLUSION: Normal reference range of uterine artery Doppler in healthy singleton pregnancies from Northeast Brazil was established. The 95th percentile of UtA-PI and UtA-RI values may serve as a cut-off for future prediction of pregnancy complications studies (i.e., pre-eclampsia) in Northeast Brazil.

【 授权许可】

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