Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma

Revista do Colégio Brasileiro de Cirurgiões

Leandro Totti Cavazzola¹  André Ricardo Pereira Da Rosa¹  Carlos Cauduro Schirmer¹  Richard Ricachenevski Gurski¹  João Pedro Bueno Telles¹  Fernando Mielke¹  Luíse Meurer²  Maria Isabel Albano Edelweiss¹  Cleber Dario Pinto Kruel¹ 

[1] ,UFRGS Departamento de PatologiaRS ,BR

关键词: Esophageal neoplasms;    Prognosis;    Genes p53;    Vascular endothelial growth factor A;    Survivorship;    Neoplasias esofágicas;    Prognóstico;    Genes p53;    Fator A de crescimento do endotélio vascular;    Sobrevida;   

DOI  :  10.1590/S0100-69912009000100007

来源: SciELO

【 摘 要 】

OBJECTIVES: To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma. METHODS: Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively. RESULTS: P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival. CONCLUSION: The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.

【 授权许可】

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