ATRIBUIÇÃO DA ESTEREOQUÍMICA DA α-SANTONINA ATRAVÉS DAS MEDIDAS DO ACOPLAMENTO DIPOLAR RESIDUAL

Química Nova

Rubens R. Teles¹  José A. A. França¹  Armando Navarro-vázquez¹  Fernando Hallwass¹ 

关键词: RDC;    NMR;    α-santonin;    natural products;   

DOI  :  10.5935/0100-4042.20150154

来源: SciELO

【 摘 要 】

The measurement of nuclear magnetic resonance parameters in an anisotropic media, such as residual dipolar coupling (RDC), has proven to be an excellent methodology for the refinement of chemical structures, being used as a complementary tool in the determination of the relative configuration, conformation, and constitution of organic compounds. In this study, we applied this methodology to determine the relative configuration of α-santonin, a natural product with four stereocenters, while assigning its prochiral methylene protons using only the RDCs obtained in a polyacrylonitrile polymer gel swollen in DMSO-d6.

【 授权许可】

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