SPECTROSCOPIC STUDY OF ALUMINUM PHTHALOCYANINE CHLORIDE (AlPcCl) IN HOMOGENEOUS AND MICRO-HETEROGENEOUS MEDIA CONSISTING OF P-123 AND F-127 POLYMERIC MICELLES

Química Nova

Bruno H. Vilsinski¹  Adriana P. Gerola¹  Évelin O. Lemos¹  Patrícia M. Barbosa¹  Katieli S. S. Campanholi¹  Gabriel B. César¹  Noboru Hioka¹  Wilker Caetano¹ 

关键词: aluminum phthalocyanine chloride;    polymeric micelles;    self-aggregation;    photodynamic therapy;   

DOI  :  10.5935/0100-4042.20150056

来源: SciELO

【 摘 要 】

Aluminum phthalocyanine chloride (AlPcCl) is a photoactive compound which has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Its spectroscopic properties have been studied in solvents of different polarities (ethanol, acetone, dimethylsulfoxide and chloroform). Its solubility has been found to decrease with increasing solvent polarity, together with full self-aggregation in aqueous solution. The binding of AlPcCl to the copolymer Pluronic^TM micellar class P-123 and F-127 used as solubilizer/carriers was studied. Greater interaction between the more hydrophobic copolymer P-123 and AlPcCl was observed, besides a complex interaction profile involving different AlPcCl forms (self-aggregate/monomeric form) in the copolymers. Time- and temperature-dependent structural organization of AlPcCl in the copolymers was also observed. Thus, AlPcCl has a strong tendency to self-aggregate with increasing solvent polarity, an effect also observed in micellar media.

【 授权许可】

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