DISTRIBUIÇÃO, ATIVIDADE BIOLÓGICA, SÍNTESE E MÉTODOS DE PURIFICAÇÃO DE PODOFILOTOXINA E SEUS DERIVADOS

Química Nova

Héctor Hugo S. Medrado¹  Jorge M. David¹  Juceni P. David¹  Hugo N. Brandão¹ 

关键词: podophyllotoxin;    etoposide;    Etopophos;    teniposide;    anticancer;   

DOI  :  10.5935/0100-4042.20140294

来源: SciELO

【 摘 要 】

Podophyllotoxin is the most studied lignan because of its use as an antimitotic agent and because it is a precursor of pharmacologically active derivatives. This review describes the anticancer activities of podophyllotoxin and the different processes that have been developed for its extraction and purification from Podophyllum spp. In addition, the synthesis routes of this compound and the development of three semi-synthetic procedures to obtain etoposide, teniposide, and Etopophos are detailed.

【 授权许可】

CC BY-NC   
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